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Article

The Evolution of Innate Immune Genes: Purifying and Balancing Selection on β-Defensins in Waterfowl.

Molecular biology and evolution - 1 Dec 2016

Chapman Joanne R, Hellgren Olof, Helin Anu S, Kraus Robert H S, Cromie Ruth L, Waldenström Jonas

Abstract excerpt

In disease dynamics, high immune gene diversity can confer a selective advantage to hosts in the face of a rapidly evolving and diverse pathogen fauna. This is supported empirically for genes involved in pathogen recognition and signalling. In contrast, effector genes involved in pathogen clearance may be more constrained. β-Defensins are innate immune effector genes; their main mode of action is via disruption...

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PMID: 27524825
DOI: 10.1093/molbev/msw167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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