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Structural evolution of an immune evasion determinant shapes pathogen host tropism

26 Jun 2023

Abstract excerpt

Modern infectious disease outbreaks often involve changes in host tropism, the preferential adaptation of pathogens to specific hosts. The Lyme disease-causing bacterium Borrelia burgdorferi ( Bb ) is an ideal model to investigate the molecular mechanisms of host tropism, because different variants of these tick-transmitted bacteria are distinctly maintained in rodents or bird reservoir hosts. To survive in hosts...

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PMID: 37364114
DOI: 10.1073/pnas.2301549120

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