Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fast, adaptive evolution at a bacterial host-resistance locus: the PFam54 gene array in Borrelia burgdorferi.

Gene - 15 Sept 2009

Wywial Ewa, Haven James, Casjens Sherwood R, Hernandez Yozen A, Singh Shaneen, Mongodin Emmanuel F, Fraser-Liggett Claire M, Luft Benjamin J, Schutzer Steven E, Qiu Wei-Gang

Abstract excerpt

Microbial pathogens have evolved sophisticated mechanisms for evasion of host innate and adaptive immunities. PFam54 is the largest paralogous gene family in the genomes of Borrelia burgdorferi, the Lyme disease bacterium. One member of PFam54, the complement-regulator acquiring surface proteins 1 (BbCrasp-1), is able to abort the alternative pathway of complement activation via binding human complement-regulator...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to Bacterial Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Borrelia burgdorferi

Share to Complement C3b Inactivator Proteins

Share to Complement Factor H

Share to Host-Pathogen Interactions

Share to Immunity, Innate

Share to Lyme Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 19505540
DOI: 10.1016/j.gene.2009.05.017
PMCID: PMC2743244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fast, adaptive evolution at a bacterial host-resistance locus: the PFam54 gene array in Borrelia burgdorferi.PMID 19505540Read ↗

Unprecedented genetic diversity suggests importance of understudied PFam54 paralogs to Lyme borreliosis spirochetesSemantic proximity Read ↗

Natural genetic variation impacts complement inhibitory activity of PFam54 orthologs of Asian Borrelia bavariensis.Semantic proximity Read ↗

Phylogenomic diversity elucidates mechanistic insights into Lyme borreliae host associationSemantic proximity Read ↗

Host tropism determination by convergent evolution of immunological evasion in the Lyme disease systemSemantic proximity Read ↗

Plasticity in early immune evasion strategies of a bacterial pathogenSemantic proximity Read ↗

Borrelia burgdorferi complement regulator-acquiring surface proteins (BbCRASPs): Expression patterns during the mammal–tick infection cycleSemantic proximity Read ↗

Borrelia burgdorferi and Treponema pallidum: a comparison of functional genomics, environmental adaptations, and pathogenic mechanisms.Semantic proximity Read ↗

Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropismSemantic proximity Read ↗

Adaptation to Host-Specific Bacterial Pathogens Drives Rapid Evolution of a Human Innate Immune ReceptorSemantic proximity Read ↗

Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.Semantic proximity Read ↗

Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance of<i>Borrelia burgdorferi</i>Semantic proximity Read ↗

Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.