The portrait of liver cancer is shaped by mitochondrial genetics

Abstract excerpt

Cancer heterogeneity and evolution are not fully understood. Here, we show that mitochondrial DNA of the normal liver shapes tumor progression, histology, and immune environment prior to the acquisition of oncogenic mutation. Using conplastic mice, we show that mtDNA dictates the expression of the mitochondrial unfolded protein response (UPR mt ) in the normal liver. Activation of oncogenic mutations in UPR mt...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endoplasmic Reticulum Stress and Disease
• Share to Ferroptosis and cancer prognosis
• Share to Ubiquitin and proteasome pathways