Article

Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation

2026-03-27

Abstract excerpt

Inflammation is a key driver of hematopoietic dysfunction in myeloid malignancies, but its role in the context of hypomethylating therapy remains incompletely understood. Although 5-Azacytidine is used posttransplant in high-risk myelodysplastic syndrome (MDS), only 50% of patients show a clinical response. We provide evidence that inherent inflammatory properties of healthy donor CD34 + stem cells exist that are...

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Literature Corpus work: 385f26f8-4519-51eb-a7d3-0e6de33d97c4
DOI: 10.64898/2026.03.25.714180

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Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiationDOI 10.64898/2026.03.25.714180Read

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