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Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis

22 Sept 2021

Abstract excerpt

Aging-elevated DNMT3A R882H-driven clonal hematopoiesis (CH) is a risk factor for myeloid malignancies remission and overall survival. Although some studies were conducted to investigate this phenomenon, the exact mechanism is still under debate. In this study, we observed that DNMT3A R878H bone marrow cells (human allele: DNMT3A R882H) displayed enhanced reconstitution capacity in aged bone marrow milieu and...

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PMID: 35256939
DOI: 10.1016/j.apsb.2021.09.015

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