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Article

Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss.

Cell - 11 Jul 2024

Wang Hui, Divaris Kimon, Pan Bohu, Li Xiaofei, Lim Jong-Hyung, Saha Gundappa, Barovic Marko, Giannakou Danai, Korostoff Jonathan M, Bing Yu, Sen Souvik, Moss Kevin, Wu Di, Beck James D, Ballantyne Christie M, Natarajan Pradeep, North Kari E, Netea Mihai G, Chavakis Triantafyllos, Hajishengallis George

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) arises from aging-associated acquired mutations in hematopoietic progenitors, which display clonal expansion and produce phenotypically altered leukocytes. We associated CHIP-DNMT3A mutations with a higher prevalence of periodontitis and gingival inflammation among 4,946 community-dwelling adults. To model DNMT3A-driven CHIP, we used mice with the...

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Identifiers

PMID: 38838669
DOI: 10.1016/j.cell.2024.05.003
PMCID: PMC11246233

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