Article

Oncostatin M is a Master Regulator of an Inflammatory Network in <i>Dnmt3a</i> -Mutant Hematopoietic Stem Cells

2023-07-12

Abstract excerpt

<h4>ABSTRACT</h4> Age-associated clonal hematopoiesis (CH) occurs due to somatic mutations accrued in hematopoietic stem cells (HSCs) that confer a selective advantage in the context of aging. The mechanisms by which CH-mutant HSCs gain this advantage with aging are not comprehensively understood. Using unbiased transcriptomic approaches, we identify Oncostatin M (OSM) signaling as a candidate contributor to agin...

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Literature Corpus work: 994ad209-bf0b-513c-868d-c80803240873
DOI: 10.1101/2023.07.12.548764

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