Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflammatory bowel disease-induced inflammation augments clonal hematopoiesis of indeterminate potential through Ref-1.

Blood - 14 May 2026

Kumar Ramesh, Li Linke, Urbut Sarah, Uddin Mesbah, Niroula Abhishek, Kanumuri Rahul, Ramdas Baskar, Pasupuleti Santhosh Kumar, Palam Lakshmi Reddy, Wang Xuepeng, Ram Padam Kanaka Sai, Kelley Mark, Natarajan Pradeep, Yu Zhi, Kapur Reuben

Abstract excerpt

ABSTRACT: Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by age-related somatic mutations in hematopoietic stem and progenitor cells (HSC/Ps) and is correlated with an increased risk of myeloid malignancies, elevated inflammatory pathways in circulating myeloid cells, higher all-cause mortality, chronic kidney disease, and cardiovascular disease. The pathophysiology of inflammatory bowel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Hematopoiesis
Share to Dioxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3A

Share to Hematopoietic Stem Cells

Share to Inflammation

Share to Inflammatory Bowel Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 41746260
DOI: 10.1182/blood.2025032339
PMCID: PMC13237589

Genes

DNMT3A
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflammatory bowel disease-induced inflammation augments clonal hematopoiesis of indeterminate potential through Ref-1.PMID 41746260Read ↗

Clonal Hematopoiesis of Indeterminate Potential in Crohn’s Disease and Ulcerative ColitisSemantic proximity Read ↗

Clonal Hematopoiesis of Indeterminate Potential in Crohn’s Disease and Ulcerative ColitisSemantic proximity Read ↗

Current Understanding of CHIP's Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature.Semantic proximity Read ↗

Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients.Semantic proximity Read ↗

Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease.Semantic proximity Read ↗

Clonal hematopoiesis of indeterminate potential: contribution to disease and promising interventionsSemantic proximity Read ↗

Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular riskSemantic proximity Read ↗

Clonal hematopoiesis of indeterminate potential: a multisystem hub bridging hematopoietic dysfunction with non-hematopoietic diseases.Semantic proximity Read ↗

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.Semantic proximity Read ↗

Clonal hematopoiesis and associated diseases: A review of recent findings.Semantic proximity Read ↗

Clonal hematopoiesis and inflammation: Partners in leukemogenesis and comorbiditySemantic proximity Read ↗

CHIP In cardiovascular and immune ageing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.