Innate immune mechanisms hijacked by leukemia-initiating stem cells for selective advantage and immune evasion in Ptpn11-associated JMML.

doi:10.1016/j.celrep.2025.116087

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Article

Innate immune mechanisms hijacked by leukemia-initiating stem cells for selective advantage and immune evasion in Ptpn11-associated JMML.

Cell reports - 26 Aug 2025

Zheng Hong, Zhao Peng, Tan Zhenya, Yu Wen-Mei, Werner Juwita, Stieglitz Elliot, Porter Christopher C, Chandrakasan Shanmuganathan, Wechsler Daniel S, Mendez-Ferrer Simon, Qu Cheng-Kui

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) originates from mutated hematopoietic stem cells. The mechanism by which mutant stem cells are sustained, leading to leukemia development, remains elusive. By comprehensively examining transcriptomic profiles, cell compositions, developmental trajectories, and cell-cell interactions across various stages of tumor cell development in a mouse model of Ptpn11...

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Topics

Animals
Immunity, Innate
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Mice
Leukemia, Myelomonocytic, Juvenile

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neoplastic Stem Cells

Immune Evasion

Calgranulin A

Calgranulin B

Mutation

Signal Transduction

Mice, Inbred C57BL

Humans

Source

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Identifiers

PMID: 40748755
DOI: 10.1016/j.celrep.2025.116087
PMCID: PMC12434698

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