Article

A soluble bi-specific fusion protein for the improved expansion of human CD8 <sup>+</sup> CAR-T cells

2026-06-19

Abstract excerpt

The success of Chimeric Antigen Receptor (CAR) T cell therapy is heavily dependent on the quality of the final cellular product. Current expansion protocols often rely on reagents that require removal from cell culture media, posing logistical challenges in manufacturing, and can also lead to terminal differentiation. Here, we evaluate the use of a soluble, bead-free T cell activator, T cell expansion protein (T-C...

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Literature Corpus work: 44c21686-5c03-5f0d-8102-abe47d44bfb1
DOI: 10.64898/2026.06.16.26355813

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