Article
Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia.
Cancer immunology, immunotherapy : CII - 1 Jul 2018
Blaeschke Franziska, Stenger Dana, Kaeuferle Theresa, Willier Semjon, Lotfi Ramin, Kaiser Andrew Didier, Assenmacher Mario, Döring Michaela, Feucht Judith, Feuchtinger Tobias
Abstract excerpt
Relapsed/refractory B-precursor acute lymphoblastic leukemia (pre-B ALL) remains a major therapeutic challenge. Chimeric antigen receptor (CAR) T cells are promising treatment options. Central memory T cells (Tcm) and stem cell-like memory T cells (Tscm) are known to promote sustained proliferation and persistence after T-cell therapy, constituting essential preconditions for treatment efficacy. Therefore, we set...
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