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Article

T Cell Activators Exhibit Distinct Downstream Effects on Chimeric Antigen Receptor T Cell Phenotype and Function.

ImmunoHorizons - 1 Jun 2024

Underwood Sarah, Jin Jianjian, Shao Lipei, Prochazkova Michaela, Shi Rongye, Song Hannah W, Jin Ping, Shah Nirali N, Somerville Robert P, Stroncek David F, Highfill Steven L

Abstract excerpt

T cell activation is an essential step in chimeric Ag receptor (CAR) T (CAR T) cell manufacturing and is accomplished by the addition of activator reagents that trigger the TCR and provide costimulation. We explore several T cell activation reagents and examine their effects on key attributes of CAR T cell cultures, such as activation/exhaustion markers, cell expansion, gene expression, and transduction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 38864817
DOI: 10.4049/immunohorizons.2400008
PMCID: PMC11220740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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