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Article

Differences in the phenotypes and transcriptomic signatures of chimeric antigen receptor T lymphocytes manufactured via electroporation or lentiviral transfection.

Frontiers in immunology - 1 Jan 2023

Niu Anna, Zou Jintao, Hu Xuan, Zhang Zhang, Su Lingyu, Wang Jing, Lu Xing, Zhang Wei, Chen Wei, Zhang Xiaopeng

Abstract excerpt

Chimeric antigen receptor (CAR)-T cell therapy is an innovative treatment for CD19-expressing lymphomas. CAR-T cells are primarily manufactured via lentivirus transfection or transposon electroporation. While anti-tumor efficacy comparisons between the two methods have been conducted, there is a current dearth of studies investigating the phenotypes and transcriptome alterations induced in T cells by the two...

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Identifiers

PMID: 37228617
DOI: 10.3389/fimmu.2023.1068625
PMCID: PMC10203401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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