Article

Cell-derived Nanoparticles Provide a Robust Platform to Manufacture Therapeutic T cells.

2026-02-04

Abstract excerpt

<title>Abstract</title> <p>Some patients cannot receive T cell therapies because their cells are unable to be manufactured. To address this limitation, we developed K562-based artificial antigen-presenting cells (aAPCs) expressing an OKT3-derived scFv for TCR stimulation, CD86 and 4-1BBL for costimulation, and membrane-bound IL-7 and IL-15Rα/IL-15 for cytokine support. From these aAPCs, we generated cell-derived...

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Literature Corpus work: c0a4b951-174a-5fb5-ac8c-3b1f8001c149
DOI: 10.21203/rs.3.rs-8436008/v1

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