Article

Mutation of NEKL-4/NEK10 and TTLL genes opposes loss of the CCPP-1 deglutamylase and prevents neuronal ciliary degeneration

2020-05-22

Abstract excerpt

Ciliary microtubules are subject to post-translational modifications that act as a “Tubulin Code” to regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, a c ytosolic c arboxy p eptidase and tubulin deglutamylating enzyme, causes infantile-onset neurodegeneration. In C. elegans, mutations in ccpp-1 , the homolog of CCP1, result in progressive degeneration of neuronal cilia and loss...

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Literature Corpus work: 44b052a9-521a-51ef-8212-934fe5229817
DOI: 10.1101/2020.05.21.108449

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Mutation of NEKL-4/NEK10 and TTLL genes opposes loss of the CCPP-1 deglutamylase and prevents neuronal ciliary degenerationDOI 10.1101/2020.05.21.108449Read

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