Article
Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
PLoS genetics - 1 Oct 2020
Power Kade M, Akella Jyothi S, Gu Amanda, Walsh Jonathon D, Bellotti Sebastian, Morash Margaret, Zhang Winnie, Ramadan Yasmin H, Ross Nicole, Golden Andy, Smith Harold E, Barr Maureen M, O'Hagan Robert
Abstract excerpt
Ciliary microtubules are subject to post-translational modifications that act as a "Tubulin Code" to regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, a cytosolic carboxypeptidase and tubulin deglutamylating enzyme, causes infantile-onset neurodegeneration. In C. elegans, mutations in ccpp-1, the homolog of CCP1, result in progressive degeneration of neuronal cilia and loss of...
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