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Article

TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice.

PLoS genetics - 1 Apr 2022

Wu Hui-Yuan, Rong Yongqi, Bansal Parmil K, Wei Peng, Guo Hong, Morgan James I

Abstract excerpt

Polyglutamylation is a dynamic posttranslational modification where glutamate residues are added to substrate proteins by 8 tubulin tyrosine ligase-like (TTLL) family members (writers) and removed by the 6 member Nna1/CCP family of carboxypeptidases (erasers). Genetic disruption of polyglutamylation leading to hyperglutamylation causes neurodegenerative phenotypes in humans and animal models; the best...

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PMID: 35404950
DOI: 10.1371/journal.pgen.1010144
PMCID: PMC9022812

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TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice.PMID 35404950Read ↗

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