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Article

Neurons dispose of hyperactive kinesin into glial cells for clearance.

The EMBO journal - 1 Jul 2024

Xie Chao, Chen Guanghan, Li Ming, Huang Peng, Chen Zhe, Lei Kexin, Li Dong, Wang Yuhe, Cleetus Augustine, Mohamed Mohamed Aa, Sonar Punam, Feng Wei, Ökten Zeynep, Ou Guangshuo

Abstract excerpt

Microtubule-based kinesin motor proteins are crucial for intracellular transport, but their hyperactivation can be detrimental for cellular functions. This study investigated the impact of a constitutively active ciliary kinesin mutant, OSM-3CA, on sensory cilia in C. elegans. Surprisingly, we found that OSM-3CA was absent from cilia but underwent disposal through membrane abscission at the tips of aberrant...

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Identifiers

PMID: 38806659
DOI: 10.1038/s44318-024-00118-0
PMCID: PMC11217292

Genes

OSM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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