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Article

TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia.

Developmental cell - 1 Jun 2009

Wloga Dorota, Webster Danielle M, Rogowski Krzysztof, Bré Marie-Hélène, Levilliers Nicolette, Jerka-Dziadosz Maria, Janke Carsten, Dougan Scott T, Gaertig Jacek

Abstract excerpt

In most ciliated cell types, tubulin is modified by glycylation, a posttranslational modification of unknown function. We show that the TTLL3 proteins act as tubulin glycine ligases with chain-initiating activity. In Tetrahymena, deletion of TTLL3 shortened axonemes and increased their resistance to paclitaxel-mediated microtubule stabilization. In zebrafish, depletion of TTLL3 led to either shortening or loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19531357
DOI: 10.1016/j.devcel.2009.04.008

Genes

TTLL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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