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Article

NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons.

The Journal of cell biology - 2 Sept 2024

Power Kaiden M, Nguyen Ken C, Silva Andriele, Singh Shaneen, Hall David H, Rongo Christopher, Barr Maureen M

Abstract excerpt

Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-onset neurodegeneration. In C. elegans, ccpp-1 loss causes age-related ciliary degradation that is suppressed by a mutation in the conserved NEK10 homolog nekl-4. NEKL-4 is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38767515
DOI: 10.1083/jcb.202402006
PMCID: PMC11104396

Genes

NEK10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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