Loss of MEC-17 leads to microtubule instability and axonal degeneration.

doi:10.1016/j.celrep.2013.12.004

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Loss of MEC-17 leads to microtubule instability and axonal degeneration.

Cell reports - 16 Jan 2014

Neumann Brent, Hilliard Massimo A

Abstract excerpt

Axonal degeneration arises as a consequence of neuronal injury and is a common hallmark of a number of neurodegenerative diseases. However, the genetic causes and the cellular mechanisms that trigger this process are still largely unknown. Based on forward genetic screening in C. elegans, we have identified the α-tubulin acetyltransferase gene mec-17 as causing spontaneous, adult-onset, and progressive axonal...

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Loss of MEC-17 leads to microtubule instability and axonal degeneration.

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Loss of MEC-17 leads to microtubule instability and axonal degeneration.

Abstract excerpt

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