Article

NEKL-4 regulates microtubule stability and mitochondrial health in <i>C. elegans</i> ciliated neurons

2024-02-14

Abstract excerpt

Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-onset neurodegeneration. In C. elegans, ccpp-1 loss causes age-related ciliary degradation that is suppressed by mutation in the conserved NEK10 homolog nekl-4 . NEKL-4 is absen...

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Literature Corpus work: 001ec099-03b9-5641-84a4-580f7155f61b
DOI: 10.1101/2024.02.14.580304

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