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Article

The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans.

Current biology : CB - 25 Oct 2011

O'Hagan Robert, Piasecki Brian P, Silva Malan, Phirke Prasad, Nguyen Ken C Q, Hall David H, Swoboda Peter, Barr Maureen M

Abstract excerpt

BACKGROUND: Posttranslational modifications (PTMs) such as acetylation, detyrosination, and polyglutamylation have long been considered markers of stable microtubules and have recently been proposed to guide molecular motors to specific subcellular destinations. Microtubules can be deglutamylated by the cytosolic carboxypeptidase CCP1. Loss of CCP1 in mice causes cerebellar Purkinje cell degeneration. Cilia,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21982591
DOI: 10.1016/j.cub.2011.08.049
PMCID: PMC4680987

Genes

KIF17
OSM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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