Article
A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits.
American journal of human genetics - 2 Jan 2020
Dahl Andy, Nguyen Khiem, Cai Na, Gandal Michael J, Flint Jonathan, Zaitlen Noah
Abstract excerpt
Gene-environment interactions (GxE) can be fundamental in applications ranging from functional genomics to precision medicine and is a conjectured source of substantial heritability. However, unbiased methods to profile GxE genome-wide are nascent and, as we show, cannot accommodate general environment variables, modest sample sizes, heterogeneous noise, and binary traits. To address this gap, we propose a...
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