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Article

Gene-lifestyle interactions in the genomics of human complex traits.

European journal of human genetics : EJHG - 1 Jun 2022

Laville Vincent, Majarian Timothy, Sung Yun J, Schwander Karen, Feitosa Mary F, Chasman Daniel I, Bentley Amy R, Rotimi Charles N, Cupples L Adrienne, de Vries Paul S, Brown Michael R, Morrison Alanna C, Kraja Aldi T, Province Mike, Gu C Charles, Gauderman W James, Rao D C, Manning Alisa K, Aschard Hugues

Abstract excerpt

The role and biological significance of gene-environment interactions in human traits and diseases remain poorly understood. To address these questions, the CHARGE Gene-Lifestyle Interactions Working Group conducted series of genome-wide interaction studies (GWIS) involving up to 610,475 individuals across four ancestries for three lipids and four blood pressure traits, while accounting for interaction effects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35314805
DOI: 10.1038/s41431-022-01045-6
PMCID: PMC9178041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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