Article

Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells

2024-05-10

Abstract excerpt

<h4>Summary</h4> Human pluripotent stem cells (hPSCs) maintain diploid populations for generations despite a persistently high rate of mitotic errors that cause aneuploidy, or chromosome imbalances. Consequently, to maintain genome stability, aneuploidy must inhibit hPSC proliferation, but the mechanisms are unknown. Here, we surprisingly find that homogeneous aneuploid populations of hPSCs proliferate unlike ane...

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Literature Corpus work: 4464248e-5517-5f4e-b3b6-f18904d1ff2e
DOI: 10.1101/2024.05.08.593217

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