Article

RPE Differentiation is a Selective Barrier Against Aneuploid hESC

2024-09-30

Abstract excerpt

<title>Abstract</title> <p>In this study, we show that undirected differentiation of human embryonic stem cells (hESC) to retinal pigment epithelium (RPE) acts as a selective barrier against aneuploid cells. Large-scale omics analysis reveals that 3–6% of cells of genetically normal hESC cultures are aneuploid, none of which progresses through RPE differentiation except for cells with a gain of 1q. We show that w...

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Literature Corpus work: 569767b0-40a7-596d-8370-a2c0c48855f2
DOI: 10.21203/rs.3.rs-5083824/v1

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