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Article

Genetic and epigenetic instability in human pluripotent stem cells.

Human reproduction update - 1 Jan 2000

Nguyen H T, Geens M, Spits C

Abstract excerpt

BACKGROUND: There is an increasing body of evidence that human pluripotent stem cells (hPSCs) are prone to (epi)genetic instability during in vitro culture. This review aims at giving a comprehensive overview of the current knowledge on culture-induced (epi)genetic alterations in hPSCs and their phenotypic consequences. METHODS: Combinations of the following key words were applied as search criteria: human...

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Source

Identifiers

PMID: 23223511
DOI: 10.1093/humupd/dms048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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