Article

Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity

2023-09-19

Abstract excerpt

<h4>SUMMARY</h4> Gains of 1q are a highly recurrent chromosomal abnormality in human pluripotent stem cells. In this work, we show that gains of 1q impact the differentiation capacity to derivates of the three germ layers, leading to miss-specification to cranial placode and non-neural ectoderm during neuroectoderm differentiation and by poorer expression of lineage specific markers in hepatoblasts and cardiac pr...

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Literature Corpus work: 9f6fbed1-692b-5c43-9fab-2085f79f2340
DOI: 10.1101/2023.09.19.558389

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