Article

Pan-cancer multi-omics analysis identifies non-canonical oncogenic functions beyond DNA replication of the POLE2 subunit of DNA Polymerase epsilon

2025-12-12

Abstract excerpt

<h4>ABSTRACT</h4> DNA polymerase epsilon (Polε) is essential for high-fidelity leading-strand synthesis. It comprises a catalytic subunit, POLE and three accessory subunits, including POLE2. In contrast to POLE, the biological functions and clinical significance of POLE2 remain unexplored. POLE2 is vital for the assembly of Polε and for interactions with the CMG helicase. Yeast studies show that dysfunction of it...

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Literature Corpus work: 4f052357-fbb8-5741-9c65-f42ee3e7f44e
DOI: 10.64898/2025.12.09.693296

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