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G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor

22 Apr 2025

Abstract excerpt

Mutations in genome maintenance factors drive sporadic and hereditary breast cancers. Here, we searched for potential drivers based on germline DNA analysis from a cohort consisting of patients with early-onset breast cancer negative for BRCA1/BRCA2 mutations. This revealed candidate genes that subsequently were subjected to RNA interference-based (RNAi-based) phenotype screens to reveal genome integrity effects....

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PMID: 40261702
DOI: 10.1172/jci.insight.186747

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