Article

Low normal factor V enhances thrombin generation in hemophilia A by a substrate competition mechanism with factor Xa

2022-06-27

Abstract excerpt

Bleeding patterns in people with hemophilia A cannot be predicted solely by factor VIII (FVIII) levels. Some of the variance in bleeding may be attributed to differences in plasma protein composition, and specifically other coagulation factors where the normal ranges span 50-150% of the population mean. We recently used a mathematical model of thrombus formation that identified factor V (FV) levels as a strong mod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4412e604-dcf1-5114-9033-6a8829b1e525
DOI: 10.1101/2022.06.27.496845

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low normal factor V enhances thrombin generation in hemophilia A by a substrate competition mechanism with factor XaDOI 10.1101/2022.06.27.496845Read

A mathematical model of flow-mediated coagulation identifies factor V as a modifier of thrombin generation in hemophilia A:Semantic proximity Read

The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models.Semantic proximity Read

Factor V Has Anticoagulant Activity in Plasma in the Presence of TFPIα: Difference between FV1 and FV2.Semantic proximity Read

Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.Semantic proximity Read

Factor XIII and Fibrin Clot Properties in Acute Venous Thromboembolism.Semantic proximity Read

Factor IX-Padua enhances the fibrinolytic resistance of plasma clots.Semantic proximity Read

Advances in understanding the bleeding diathesis in factor V deficiencySemantic proximity Read

Sample conditions determine the ability of thrombin generation parameters to identify bleeding phenotype in FXI deficiency.Semantic proximity Read

In vitro evaluation of factor IX as novel treatment for factor XI deficiencySemantic proximity Read

A factor IX variant that functions independently of factor VIII mitigates the hemophilia A phenotype in patient plasma.Semantic proximity Read

Reduced fibrinolytic resistance in patients with factor XI deficiency. Evidence of a thrombin-independent impairment of the thrombin-activatable fibrinolysis inhibitor pathway.Semantic proximity Read

Thrombin activatable fibrinolysis inhibitor activation and bleeding in haemophilia A.Semantic proximity Read