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Article

Factor IX-Padua enhances the fibrinolytic resistance of plasma clots.

Thrombosis and haemostasis - 1 Feb 2014

Ammollo Concetta T, Semeraro Fabrizio, Colucci Mario, Simioni Paolo

Abstract excerpt

Hypercoagulable conditions may determine a hypofibrinolytic state by increasing the activation of thrombin-activatable fibrinolysis inhibitor (TAFI). Factor (F)IX-Padua is a mutated FIX with an eight-fold increased clotting activity and associates with a higher venous thrombotic risk. We evaluated the influence of FIX-Padua on TAFI-mediated regulation of fibrinolysis. A subject hemizygous for FIX-Padua, two...

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Identifiers

PMID: 24136406
DOI: 10.1160/TH13-06-0489

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