Article
Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.
Blood - 1 Nov 2008
Duckers Connie, Simioni Paolo, Spiezia Luca, Radu Claudia, Gavasso Sabrina, Rosing Jan, Castoldi Elisabetta
Abstract excerpt
Severe factor V (FV) deficiency is associated with mild to severe bleeding diathesis, but many patients with FV levels lower than 1% bleed less than anticipated. We used calibrated automated thrombography to screen patients with severe FV deficiency for protective procoagulant defects. Thrombin generation in FV-deficient plasma was only measurable at high tissue factor concentrations. Upon reconstitution of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.