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Article

The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models.

PloS one - 1 Jan 2013

Onasoga-Jarvis Abimbola A, Leiderman Karin, Fogelson Aaron L, Wang Michael, Manco-Johnson Marilyn J, Di Paola Jorge A, Neeves Keith B

Abstract excerpt

Clinical evidence suggests that individuals with factor VIII (FVIII) deficiency (hemophilia A) are protected against venous thrombosis, but treatment with recombinant proteins can increase their risk for thrombosis. In this study we examined the dynamics of thrombus formation in individuals with hemophilia A and their response to replacement and bypass therapies under venous flow conditions. Fibrin and platelet...

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Identifiers

PMID: 24236042
DOI: 10.1371/journal.pone.0078732
PMCID: PMC3827262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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