Factor XIII and Fibrin Clot Properties in Acute Venous Thromboembolism.

doi:10.3390/ijms22041607

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Article

Factor XIII and Fibrin Clot Properties in Acute Venous Thromboembolism.

International journal of molecular sciences - 5 Feb 2021

Ząbczyk Michał, Natorska Joanna, Undas Anetta

Abstract excerpt

Coagulation factor XIII (FXIII) is converted by thrombin into its active form, FXIIIa, which crosslinks fibrin fibers, rendering clots more stable and resistant to degradation. FXIII affects fibrin clot structure and function leading to a more prothrombotic phenotype with denser networks, characterizing patients at risk of venous thromboembolism (VTE). Mechanisms regulating FXIII activation and its impact on...

Topics

Acute Disease
Anticoagulants
Blood Coagulation
Factor XIII
Fibrin
Fibrinolysis
Genetic Variation
Humans
Models, Cardiovascular
Venous Thromboembolism

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Identifiers

PMID: 33562624
DOI: 10.3390/ijms22041607
PMCID: PMC7914915

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