Article
Sample conditions determine the ability of thrombin generation parameters to identify bleeding phenotype in FXI deficiency.
Blood - 16 Jul 2015
Pike Gillian N, Cumming Anthony M, Hay Charles R M, Bolton-Maggs Paula H B, Burthem John
Abstract excerpt
Individuals with Factor XI (FXI) deficiency have a variable bleeding tendency that does not correlate with FXI:C levels or genotype. Comparing a range of sample conditions, we tested whether the thrombin generation assay (TGA) could discriminate between control subjects (n = 50) and FXI-deficient individuals (n = 97), and between those with bleeding tendency (n = 50) and without (n = 24). The comparison used...
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