Article

Revealing the combined roles of Aβ and tau in Alzheimer’s disease via a pathophysiological activity decoder

2023-02-22

Abstract excerpt

Neuronal dysfunction and cognitive deterioration in Alzheimer’s disease (AD) are likely caused by multiple pathophysiological factors. However, evidence in humans remains scarce, necessitating improved non-invasive techniques and integrative mechanistic models. Here, we introduce personalized brain activity models incorporating functional MRI, amyloid-β (Aβ) and tau-PET from AD-related participants (N=132). Within...

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Literature Corpus work: 43cbb02b-7af8-54fe-9e36-172789ad82c0
DOI: 10.1101/2023.02.21.529377

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