Article

Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations

2023-01-25

Abstract excerpt

Alzheimer’s disease (AD) and other tauopathies are characterized by the aggregation of tau into soluble and insoluble forms (including tangles and neuropil threads). In humans, a fraction of both phosphorylated and non-phosphorylated N-terminal to mid-domain tau species, including the aggregated forms, are secreted into cerebrospinal fluid (CSF). Some of these CSF tau species can be measured as diagnostic and prog...

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Literature Corpus work: 017a8c90-d1a1-5bc1-a77b-5db1f96db466
DOI: 10.1101/2023.01.24.525362

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