Article

Subject-specific features of excitation/inhibition profiles in neurodegenerative diseases

2021-12-23

Abstract excerpt

Brain pathologies are based on microscopic changes in neurons and synapses that reverberate into large scale networks altering brain dynamics and functional states. An important yet unresolved issue concerns the impact of patients excitation/inhibition profiles on neurodegenerative diseases including Alzheimer’s disease, Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. In this work we used a simulation p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38673493-5c1d-545a-b460-c5a8de13c66a
DOI: 10.1101/2021.12.23.473997

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Subject-specific features of excitation/inhibition profiles in neurodegenerative diseasesDOI 10.1101/2021.12.23.473997Read

Model-based whole-brain perturbational landscape of neurodegenerative diseasesSemantic proximity Read

From genes to network models of Alzheimer's disease: Biological framework for multi-scale brain simulation with The Virtual BrainSemantic proximity Read

Alterations in topological and dynamical parameters correlate with disease biomarkers and neuropsychological scores in prodromic stages of dementiaSemantic proximity Read

Revealing the combined roles of Aβ and tau in Alzheimer’s disease via a pathophysiological activity decoderSemantic proximity Read

Unveiling paths to Alzheimer’s disease: excitation-inhibition ratio shapes hierarchical dynamicsSemantic proximity Read

Neurophysiological consequences of synapse loss in progressive supranuclear palsySemantic proximity Read

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s diseaseSemantic proximity Read

Distinct effects of amyloid and tau deposition on eigenvector centrality during hippocampal down-regulation: a real-time fMRI virtual reality closed-loop neurofeedback study with CSF biomarkersSemantic proximity Read

NeuroPM toolbox: integrating Molecular, Neuroimaging and Clinical data for Characterizing Neuropathological Progression and Individual Therapeutic NeedsSemantic proximity Read

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s diseaseSemantic proximity Read

Region-specific mean field models enhance simulations of local and global brain dynamicsSemantic proximity Read

The landscape of functional brain network impairments in late-onset GM2 gangliosidosisSemantic proximity Read