Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

doi:10.4049/jimmunol.1700172

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Article

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2017

Cerosaletti Karen, Barahmand-Pour-Whitman Fariba, Yang Junbao, DeBerg Hannah A, Dufort Matthew J, Murray Sara A, Israelsson Elisabeth, Speake Cate, Gersuk Vivian H, Eddy James A, Reijonen Helena, Greenbaum Carla J, Kwok William W, Wambre Erik, Prlic Martin, Gottardo Raphael, Nepom Gerald T, Linsley Peter S

Abstract excerpt

The significance of islet Ag-reactive T cells found in peripheral blood of type 1 diabetes (T1D) subjects is unclear, partly because similar cells are also found in healthy control (HC) subjects. We hypothesized that key disease-associated cells would show evidence of prior Ag exposure, inferred from expanded TCR clonotypes, and essential phenotypic properties in their transcriptomes. To test this, we developed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28566371
DOI: 10.4049/jimmunol.1700172
PMCID: PMC5499675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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