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LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking

6 Jan 2016

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 ( lrrk2) gene cause inherited Parkinson's disease (PD), and common variants in lrrk2 are a risk factor for sporadic PD. The neuropathology associated with LRRK2-linked PD is extremely pleomorphic involving inclusions of α-synuclein (SNCA), tau or neither, therefore suggesting that LRRK2 may be central in the pathogenic pathways of PD. This large protein localizes in the...

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PMID: 26740081
DOI: 10.1177/1073858415616558

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