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Article

TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell niche

2025-09-09

Abstract excerpt

<h4>BACKGROUND & AIMS</h4> Anti-tumor necrosis factor (anti-TNF) is a mainstay of inflammatory bowel disease (IBD) therapy but fails in many patients. Although TNF has pro-inflammatory effects, depletion of TNF receptor 1 (TNFR1) paradoxically exacerbates chronic colitis. Because colitis induces remodeling of mesenchymal cell populations, which provide a niche for epithelial stem cells involved in mucosal healing...

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Literature Corpus work
ca6c0146-5ba6-5fd6-a276-7479cac5877e
DOI
10.1101/2025.09.08.674957
Open publication

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TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell nicheDOI 10.1101/2025.09.08.674957
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