Article
Genome-wide identification of autosomal genes with allelic imbalance of chromatin state.
PloS one - 1 Jan 2017
Savol Andrej J, Wang Peggy I, Jeon Yesu, Colognori David, Yildirim Eda, Pinter Stefan F, Payer Bernhard, Lee Jeannie T, Sadreyev Ruslan I
Abstract excerpt
In mammals, monoallelic gene expression can result from X-chromosome inactivation, genomic imprinting, and random monoallelic expression (RMAE). Epigenetic regulation of RMAE is not fully understood. Here we analyze allelic imbalance in chromatin state of autosomal genes using ChIP-seq in a clonal cell line. We identify approximately 3.7% of autosomal genes that show significant differences between chromatin...
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