Article
Locus specific epigenetic modalities of random allelic expression imbalance.
Nature communications - 9 Sept 2021
Marion-Poll Lucile, Forêt Benjamin, Zielinski Dina, Massip Florian, Attia Mikael, Carter Ava C, Syx Laurène, Chang Howard Y, Gendrel Anne-Valerie, Heard Edith
Abstract excerpt
Most autosomal genes are thought to be expressed from both alleles, with some notable exceptions, including imprinted genes and genes showing random monoallelic expression (RME). The extent and nature of RME has been the subject of debate. Here we investigate the expression of several candidate RME genes in F1 hybrid mouse cells before and after differentiation, to define how they become persistently,...
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