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Article

Monoallelic Gene Expression: Stochastic or Clonal? From Detection to Mechanisms and Clinical Significance.

International journal of molecular sciences - 14 Jul 2026

Zemlianaia Olga A, Strelnikov Vladimir V, Zaletaev Dmitry V, Nemtsova Marina V

Abstract excerpt

There are several forms of monoallelic expression, in which the 50:50 ratio in the expression activity of each of the two copies of the gene is disrupted. This review focuses on the phenomenon of random autosomal monoallelic expression (aRME), a process in which only one of the two alleles is transcribed in a single cell, and the allele choice is not determined by the parental origin. One of the central problems...

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Identifiers

PMID: 42511605
DOI: 10.3390/ijms27146262
PMCID: PMC13410931

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