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Structure of the measles virus ternary polymerase complex

23 Apr 2025

Abstract excerpt

Measles virus (MeV) is a highly contagious pathogen that causes significant morbidity worldwide. Its polymerase machinery, composed of the large protein (L) and phosphoprotein (P), is crucial for viral replication and transcription, making it a promising target for antiviral drug development. Here we present cryo-electron microscopy structures of two distinct MeV polymerase complexes: Lcore-P and Lfull-P-C. The...

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PMID: 40268911
DOI: 10.1038/s41467-025-58985-y

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