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Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

17 Jul 2020

Abstract excerpt

Bunyavirales is an order of segmented negative-strand RNA viruses comprising several life-threatening pathogens against which no effective treatment is currently available. Replication and transcription of the RNA genome constitute essential processes performed by the virally encoded multi-domain RNA-dependent RNA polymerase. Here, we describe the complete high-resolution cryo-EM structure of La Crosse virus...

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PMID: 32681014
DOI: 10.1038/s41467-020-17349-4

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