Article

The RZZ complex facilitates Mad1 binding to Bub1 ensuring efficient checkpoint signaling

2018-05-15

Abstract excerpt

<h4>Introductory paragraph</h4> The recruitment of Mad1 to unattached kinetochores is essential for generating a “wait anaphase” signal during mitosis yet Mad1 localization is poorly understood in mammalian cells. In yeast the Bub1 checkpoint protein is the sole Mad1 receptor but in mammalian cells the Rod-ZW10-Zwilch (RZZ) complex is also required for Mad1 kinetochore localization. The exact function of the two...

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Literature Corpus work: a8c2a5e7-c143-5a51-becb-36f4f0b1c6c7
DOI: 10.1101/322834

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